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Very often (particularly after periods of low rainfall) the malaria risk in Kruger is very low. Many people decide not to take prophylactics and rather try to avoid getting bitten. The most vulnerable times are between dusk and dawn. People are advised to stay indoors during these periods, or cover exposed skin with light clothing or insect repellants. The ankles are the most critical area. Burning anti-mosquito coils and ensuring netted screens are kept closed are other preventative measures.

While malaria prophylactics are recommended, no prophylactic is foolproof and any person developing flu-like symptoms 7 to 20 days (or even longer) after being in malaria areas should be tested immediately for malaria, until the symptoms clear or an alternative diagnosis is made. It is important to advise medical practitioners that you have been in a malaria area to avoid incorrect diagnosis.